Repurposing of Ibrutinib and Quizartinib as potent inhibitors of necroptosis

Necroptosis is a form of regulated cell death that has been implicated in multiple diseases. TNF-induced necroptosis is regulated by necrosomes, complexes consisting of RIPK1, RIPK3 and MLKL. In this study, by screening of a small-compound library, we identified dozens of compounds that inhibited TN...

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Detalles Bibliográficos
Autores principales: Huang, Fangmin, Liang, Jiankun, Lin, Yingying, Chen, Yushi, Hu, Fen, Feng, Jianting, Zeng, Qiang, Han, Zeteng, Lin, Qiaofa, Li, Yan, Li, Jingyi, Wu, Lanqin, Li, Lisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517925/
https://www.ncbi.nlm.nih.gov/pubmed/37741898
http://dx.doi.org/10.1038/s42003-023-05353-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517925/
https://www.ncbi.nlm.nih.gov/pubmed/37741898
http://dx.doi.org/10.1038/s42003-023-05353-5

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