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Repurposing of Ibrutinib and Quizartinib as potent inhibitors of necroptosis
Necroptosis is a form of regulated cell death that has been implicated in multiple diseases. TNF-induced necroptosis is regulated by necrosomes, complexes consisting of RIPK1, RIPK3 and MLKL. In this study, by screening of a small-compound library, we identified dozens of compounds that inhibited TN...
Autores principales: | Huang, Fangmin, Liang, Jiankun, Lin, Yingying, Chen, Yushi, Hu, Fen, Feng, Jianting, Zeng, Qiang, Han, Zeteng, Lin, Qiaofa, Li, Yan, Li, Jingyi, Wu, Lanqin, Li, Lisheng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517925/ https://www.ncbi.nlm.nih.gov/pubmed/37741898 http://dx.doi.org/10.1038/s42003-023-05353-5 |
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