GiRAFR improves gRNA detection and annotation in single-cell CRISPR screens

Novel methods that combine single cell RNA-seq with CRISPR screens enable high-throughput characterization of transcriptional changes caused by genetic perturbations. Dedicated software is however lacking to annotate CRISPR guide RNA (gRNA) libraries and associate them with single cell transcriptome...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Qian, Van Minsel, Paulien, Galle, Eva, Thienpont, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518011/
https://www.ncbi.nlm.nih.gov/pubmed/37741886
http://dx.doi.org/10.1038/s42003-023-05351-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518011/
https://www.ncbi.nlm.nih.gov/pubmed/37741886
http://dx.doi.org/10.1038/s42003-023-05351-7

Ejemplares similares