Oncometabolite D-2-hydroxyglutarate—dependent metabolic reprogramming induces skeletal muscle atrophy during cancer cachexia

Cancer cachexia is characterized by weight loss and skeletal muscle wasting. Based on the up-regulation of catabolism and down-regulation of anabolism, here we showed genetic mutation-mediated metabolic reprogramming in the progression of cancer cachexia by screening for metabolites and investigatin...

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Detalles Bibliográficos
Autores principales: Zhu, Xinting, Hao, Juan, Zhang, Hong, Chi, Mengyi, Wang, Yaxian, Huang, Jinlu, Xu, Rong, Xincai, Zhao, Xin, Bo, Sun, Xipeng, Zhang, Jianping, Zhou, Shumin, Cheng, Dongdong, Yuan, Ting, Ding, Jun, Zheng, Shuier, Guo, Cheng, Yang, Quanjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518016/
https://www.ncbi.nlm.nih.gov/pubmed/37741882
http://dx.doi.org/10.1038/s42003-023-05366-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518016/
https://www.ncbi.nlm.nih.gov/pubmed/37741882
http://dx.doi.org/10.1038/s42003-023-05366-0

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