Cargando…

Multi-omics analysis reveals attenuation of cellular stress by empagliflozin in high glucose-treated human cardiomyocytes

BACKGROUND: Sodium–glucose cotransporter 2 (SGLT2) inhibitors constitute the gold standard treatment for type 2 diabetes mellitus (T2DM). Among them, empagliflozin (EMPA) has shown beneficial effects against heart failure. Because cardiovascular diseases (mainly diabetic cardiomyopathy) are the lead...

Descripción completa

Detalles Bibliográficos
Autores principales:	Scisciola, Lucia, Chianese, Ugo, Caponigro, Vicky, Basilicata, Manuela Giovanna, Salviati, Emanuela, Altucci, Lucia, Campiglia, Pietro, Paolisso, Giuseppe, Barbieri, Michelangela, Benedetti, Rosaria, Sommella, Eduardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518098/ https://www.ncbi.nlm.nih.gov/pubmed/37742032 http://dx.doi.org/10.1186/s12967-023-04537-1

Ejemplares similares

Potential Role of Lisinopril in Reducing Atherosclerotic Risk: Evidence of an Antioxidant Effect in Human Cardiomyocytes Cell Line
por: Scisciola, Lucia, et al.
Publicado: (2022)

Sarcopenia and Cognitive Function: Role of Myokines in Muscle Brain Cross-Talk
por: Scisciola, Lucia, et al.
Publicado: (2021)

miR-21 in Human Cardiomyopathies
por: Surina,, et al.
Publicado: (2021)

Corrigendum: miR-21 in Human Cardiomyopathies
por: Surina,, et al.
Publicado: (2022)

A Multi-Omics Approach Revealed Common Dysregulated Pathways in Type One and Type Two Endometrial Cancers
por: Capaci, Valeria, et al.
Publicado: (2023)

FASN multi-omic characterization reveals metabolic heterogeneity in pancreatic and prostate adenocarcinoma
por: Chianese, Ugo, et al.
Publicado: (2023)

Adiponectin Related Vascular and Cardiac Benefits in Obesity: Is There a Role for an Epigenetically Regulated Mechanism?
por: Fontanella, Rosaria Anna, et al.
Publicado: (2021)

MALDI Mass Spectrometry Imaging Highlights Specific Metabolome and Lipidome Profiles in Salivary Gland Tumor Tissues
por: Sommella, Eduardo, et al.
Publicado: (2022)

Preclinical and Clinical Epigenetic-Based Reconsideration of Beckwith-Wiedemann Syndrome
por: Papulino, Chiara, et al.
Publicado: (2020)

Targeting redox imbalance in neurodegeneration: characterizing the role of GLP-1 receptor agonists
por: Ghosh, Puja, et al.
Publicado: (2023)

Tumor microenvironment and epithelial-mesenchymal transition in bladder cancer: Cytokines in the game?
por: Martins-Lima, Cláudia, et al.
Publicado: (2023)

Optimization of microwave-assisted extraction of antioxidant compounds from spring onion leaves using Box–Behnken design
por: Aquino, Giovanna, et al.
Publicado: (2023)

Reduction of Oxidative Stress and Inflammation by Blunting Daily Acute Glucose Fluctuations in Patients With Type 2 Diabetes: Role of dipeptidyl peptidase-IV inhibition
por: Rizzo, Maria Rosaria, et al.
Publicado: (2012)

Response to Comment on: Rizzo et al. Reduction of Oxidative Stress and Inflammation by Blunting Daily Acute Glucose Fluctuations in Patients With Type 2 Diabetes: Role of Dipeptidyl Peptidase-IV Inhibition. Diabetes Care 2012;35:2076–2082
por: Rizzo, Maria Rosaria, et al.
Publicado: (2013)

SIRT1 activation promotes energy homeostasis and reprograms liver cancer metabolism
por: Varghese, Benluvankar, et al.
Publicado: (2023)

Atherosclerotic Plaque Fissuration and Clinical Outcomes in Pre-Diabetics vs. Normoglycemics Patients Affected by Asymptomatic Significant Carotid Artery Stenosis at 2 Years of Follow-Up: Role of microRNAs Modulation: The ATIMIR Study
por: Sardu, Celestino, et al.
Publicado: (2021)

Cardiac Resynchronization Therapy Outcomes in Type 2 Diabetic Patients: Role of MicroRNA Changes
por: Sardu, Celestino, et al.
Publicado: (2016)

Targeting high glucose-induced epigenetic modifications at cardiac level: the role of SGLT2 and SGLT2 inhibitors
por: Scisciola, Lucia, et al.
Publicado: (2023)

HDAC6 Inhibition Extinguishes Autophagy in Cancer: Recent Insights
por: Passaro, Eugenia, et al.
Publicado: (2021)

I BET on anti‐FGFR to fight cancer resistance
por: Benedetti, Rosaria, et al.
Publicado: (2019)

Cardiac resynchronization therapy with a defibrillator (CRTd) in failing heart patients with type 2 diabetes mellitus and treated by glucagon-like peptide 1 receptor agonists (GLP-1 RA) therapy vs. conventional hypoglycemic drugs: arrhythmic burden, hospitalizations for heart failure, and CRTd responders rate
por: Sardu, Celestino, et al.
Publicado: (2018)

Pericoronary fat inflammation and Major Adverse Cardiac Events (MACE) in prediabetic patients with acute myocardial infarction: effects of metformin
por: Sardu, Celestino, et al.
Publicado: (2019)

Glycated ACE2 receptor in diabetes: open door for SARS-COV-2 entry in cardiomyocyte
por: D’Onofrio, Nunzia, et al.
Publicado: (2021)

Indole-3-lactic acid, a metabolite of tryptophan, secreted by Bifidobacterium longum subspecies infantis is anti-inflammatory in the immature intestine.
por: Meng, Di, et al.
Publicado: (2020)

Inhibitors of histone deacetylase 6 based on a novel 3-hydroxy-isoxazole zinc binding group
por: Linciano, Pasquale, et al.
Publicado: (2021)

Association of Genetic Variation in Adaptor Protein APPL1/APPL2 Loci with Non-Alcoholic Fatty Liver Disease
por: Barbieri, Michelangela, et al.
Publicado: (2013)

Mediterranean Diet, Telomere Maintenance and Health Status among Elderly
por: Boccardi, Virginia, et al.
Publicado: (2013)

Metabolic Pathways as a Novel Landscape in Pancreatic Ductal Adenocarcinoma
por: Ali, Ahmad, et al.
Publicado: (2022)

Effects of PPARs Agonists on Cardiac Metabolism in Littermate and Cardiomyocyte-Specific PPAR-γ –Knockout (CM-PGKO) Mice
por: Barbieri, Michelangela, et al.
Publicado: (2012)

Adiponectin Role in Neurodegenerative Diseases: Focus on Nutrition Review
por: Polito, Rita, et al.
Publicado: (2020)

Antioxidant Properties of Buffalo-Milk Dairy Products: A β-Lg Peptide Released after Gastrointestinal Digestion of Buffalo Ricotta Cheese Reduces Oxidative Stress in Intestinal Epithelial Cells
por: Basilicata, Manuela Giovanna, et al.
Publicado: (2018)

Awaking Blood Pressure Surge and Progression to Microalbuminuria in Type 2 Normotensive Diabetic Patients
por: Barbieri, Michelangela, et al.
Publicado: (2016)

Cardiac electrophysiological alterations and clinical response in cardiac resynchronization therapy with a defibrillator treated patients affected by metabolic syndrome
por: Sardu, Celestino, et al.
Publicado: (2017)

Regulatory Interplay between miR-181a-5p and Estrogen Receptor Signaling Cascade in Breast Cancer
por: Benedetti, Rosaria, et al.
Publicado: (2021)

Anti-inflammatory role of SGLT2 inhibitors as part of their anti-atherosclerotic activity: Data from basic science and clinical trials
por: Scisciola, Lucia, et al.
Publicado: (2022)

Beyond Retigabine: Design, Synthesis, and Pharmacological Characterization of a Potent and Chemically Stable Neuronal Kv7 Channel Activator with Anticonvulsant Activity
por: Musella, Simona, et al.
Publicado: (2022)

Multipolar pacing by cardiac resynchronization therapy with a defibrillators treatment in type 2 diabetes mellitus failing heart patients: impact on responders rate, and clinical outcomes
por: Sardu, Celestino, et al.
Publicado: (2017)

Citrus sinensis and Vitis vinifera Protect Cardiomyocytes from Doxorubicin-Induced Oxidative Stress: Evaluation of Onconutraceutical Potential of Vegetable Smoothies
por: Pepe, Giacomo, et al.
Publicado: (2020)

A Boost in Mitochondrial Activity Underpins the Cholesterol-Lowering Effect of Annurca Apple Polyphenols on Hepatic Cells
por: Sommella, Eduardo, et al.
Publicado: (2019)

Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane Induced Dystrophy and Hijacks Polyunsaturated Fatty Acid Metabolism toward β-Oxidation
por: Riccio, Gennaro, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ia0rq0kk9klk7d1cguarshcm3a