Cognitive enhancing effects of pazopanib in D‑galactose/ovariectomized Alzheimer’s rat model: insights into the role of RIPK1/RIPK3/MLKL necroptosis signaling pathway

Necroptosis, a programmed form of necrotic cell death carried out by receptor-interacting serine/threonine protein kinase 1 (RIPK1) and RIPK3, has been found to be implicated in the pathogenesis of Alzheimer’s disease (AD). An FDA-approved anti-cancer drug, pazopanib, is reported to possess potent i...

Descripción completa

Detalles Bibliográficos
Autores principales: Abdelhady, Rasha, Younis, Nancy S., Ali, Omaima, Shehata, Samah, Sayed, Rabab H., Nadeem, Rania I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518286/
https://www.ncbi.nlm.nih.gov/pubmed/37458952
http://dx.doi.org/10.1007/s10787-023-01269-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518286/
https://www.ncbi.nlm.nih.gov/pubmed/37458952
http://dx.doi.org/10.1007/s10787-023-01269-y

Ejemplares similares