Neuromodulatory effect of vardenafil on aluminium chloride/d-galactose induced Alzheimer’s disease in rats: emphasis on amyloid-beta, p-tau, PI3K/Akt/p53 pathway, endoplasmic reticulum stress, and cellular senescence

ABSTRACT: Dysregulation of protein homeostasis, proteostasis, is a distinctive hallmark of many neurodegenerative disorders and aging. Deleteriously, the accumulation of aberrant proteins in Alzheimer’s disease (AD) is accompanied with a marked collapse in proteostasis network. The current study exp...

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Detalles Bibliográficos
Autores principales: Awad, Heba H., Desouky, Mahmoud A., Zidan, Alaa, Bassem, Mariam, Qasem, Amaal, Farouk, Mona, AlDeab, Haidy, Fouad, Miral, Hany, Cherry, Basem, Nada, Nader, Rita, Alkalleny, Ashrakat, Reda, Verina, George, Mina Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518298/
https://www.ncbi.nlm.nih.gov/pubmed/37460908
http://dx.doi.org/10.1007/s10787-023-01287-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518298/
https://www.ncbi.nlm.nih.gov/pubmed/37460908
http://dx.doi.org/10.1007/s10787-023-01287-w

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