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Both chloride-binding sites are required for KCC2-mediated transport
The K(+)–Cl(−) cotransporter 2 (KCC2) plays an important role in inhibitory neurotransmission, and its impairment is associated with neurological and psychiatric disorders, including epilepsy, schizophrenia, and autism. Although KCCs transport K(+) and Cl(−) in a 1:1 stoichiometry, two Cl(−) coordin...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518353/ https://www.ncbi.nlm.nih.gov/pubmed/37625593 http://dx.doi.org/10.1016/j.jbc.2023.105190 |