High-titer AAV disrupts cerebrovascular integrity and induces lymphocyte infiltration in adult mouse brain

The brain is often described as an “immune-privileged” organ due to the presence of the blood-brain-barrier (BBB), which limits the entry of immune cells. In general, intracranial injection of adeno-associated virus (AAV) is considered a relatively safe procedure. In this study, we discovered that A...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Yaowei, Chen, Junliang, Ji, Wenyu, Xu, Liang, Xie, Yu, He, Shu, Lai, Chuying, Hou, Kaiyu, Li, Zeru, Chen, Gong, Wu, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518493/
https://www.ncbi.nlm.nih.gov/pubmed/37753218
http://dx.doi.org/10.1016/j.omtm.2023.08.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518493/
https://www.ncbi.nlm.nih.gov/pubmed/37753218
http://dx.doi.org/10.1016/j.omtm.2023.08.021

Ejemplares similares