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High-titer AAV disrupts cerebrovascular integrity and induces lymphocyte infiltration in adult mouse brain
The brain is often described as an “immune-privileged” organ due to the presence of the blood-brain-barrier (BBB), which limits the entry of immune cells. In general, intracranial injection of adeno-associated virus (AAV) is considered a relatively safe procedure. In this study, we discovered that A...
Autores principales: | Guo, Yaowei, Chen, Junliang, Ji, Wenyu, Xu, Liang, Xie, Yu, He, Shu, Lai, Chuying, Hou, Kaiyu, Li, Zeru, Chen, Gong, Wu, Zheng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518493/ https://www.ncbi.nlm.nih.gov/pubmed/37753218 http://dx.doi.org/10.1016/j.omtm.2023.08.021 |
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