Prioritization of therapeutic targets for dyslipidemia using integrative multi-omics and multi-trait analysis

Drug targets with genetic support are several-fold more likely to succeed in clinical trials. We introduce a genetic-driven approach based on causal inferences that can inform drug target prioritization, repurposing, and adverse effects of using lipid-lowering agents. Given that a multi-trait approa...

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Detalles Bibliográficos
Autores principales: Kim, Min Seo, Song, Minku, Kim, Beomsu, Shim, Injeong, Kim, Dan Say, Natarajan, Pradeep, Do, Ron, Won, Hong-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518515/
https://www.ncbi.nlm.nih.gov/pubmed/37582372
http://dx.doi.org/10.1016/j.xcrm.2023.101112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518515/
https://www.ncbi.nlm.nih.gov/pubmed/37582372
http://dx.doi.org/10.1016/j.xcrm.2023.101112

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