Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer’s disease via MFG-E8

Synapse loss correlates with cognitive decline in Alzheimer’s disease (AD). Data from mouse models suggests microglia are important for synapse degeneration, but direct human evidence for any glial involvement in synapse removal in human AD remains to be established. Here we observe astrocytes and m...

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Detalles Bibliográficos
Autores principales: Tzioras, Makis, Daniels, Michael J.D., Davies, Caitlin, Baxter, Paul, King, Declan, McKay, Sean, Varga, Balazs, Popovic, Karla, Hernandez, Madison, Stevenson, Anna J., Barrington, Jack, Drinkwater, Elizabeth, Borella, Julia, Holloway, Rebecca K., Tulloch, Jane, Moss, Jonathan, Latta, Clare, Kandasamy, Jothy, Sokol, Drahoslav, Smith, Colin, Miron, Veronique E., Káradóttir, Ragnhildur Thóra, Hardingham, Giles E., Henstridge, Christopher M., Brennan, Paul M., McColl, Barry W., Spires-Jones, Tara L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518633/
https://www.ncbi.nlm.nih.gov/pubmed/37652017
http://dx.doi.org/10.1016/j.xcrm.2023.101175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518633/
https://www.ncbi.nlm.nih.gov/pubmed/37652017
http://dx.doi.org/10.1016/j.xcrm.2023.101175

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