Cargando…

A fine-tuned yeast surface-display/secretion platform enables the rapid discovery of neutralizing antibodies against Clostridioides difficile toxins

BACKGROUND: Neutralizing antibody plays a key role in protecting hosts from invasive pathogens and their virulent components. Current high-throughput assays for antibody screening are based on binding activities. However, those antibodies with high affinity may not have neutralizing activities. Subs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Ying, Zhang, Yongrong, Yu, Hua, Saint Fleur, Ashley, Yu, Di, Yang, Zhiyong, Feng, Hanping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519002/ https://www.ncbi.nlm.nih.gov/pubmed/37749574 http://dx.doi.org/10.1186/s12934-023-02200-4

Ejemplares similares

The development of live biotherapeutics against Clostridioides difficile infection towards reconstituting gut microbiota
por: Zhang, Yongrong, et al.
Publicado: (2022)

Cysteine Protease-Mediated Autocleavage of Clostridium difficile Toxins Regulates Their Proinflammatory Activity
por: Zhang, Yongrong, et al.
Publicado: (2018)

Structural Basis for Binding of Neutralizing Antibodies to Clostridioides difficile Binary Toxin
por: Goldsmith, Jory A., et al.
Publicado: (2023)

Development and characterization of phage display-derived anti-toxin antibodies neutralizing TcdA and TcdB of Clostridioides difficile
por: Raeisi, Hamideh, et al.
Publicado: (2023)

Ebselen Not Only Inhibits Clostridioides difficile Toxins but Displays Redox-Associated Cellular Killing
por: Marreddy, Ravi K. R., et al.
Publicado: (2021)

An Update on Clostridioides difficile Binary Toxin
por: Martínez-Meléndez, Adrián, et al.
Publicado: (2022)

Establishment of a gnotobiotic pig model of Clostridioides difficile infection and disease
por: Nyblade, Charlotte, et al.
Publicado: (2022)

Structure and conformational dynamics of Clostridioides difficile toxin A
por: Chen, Baohua, et al.
Publicado: (2022)

Neutralizing epitopes on Clostridioides difficile toxin A revealed by the structures of two camelid VHH antibodies
por: Chen, Baohua, et al.
Publicado: (2022)

The prognostic value of toxin B and binary toxin in Clostridioides difficile infection
por: López-Cárdenas, Salvador, et al.
Publicado: (2021)

Host Immune Responses to Clostridioides difficile: Toxins and Beyond
por: Nibbering, Britt, et al.
Publicado: (2021)

Non-Toxin-Based Clostridioides difficile Vaccination Approaches
por: Razim, Agnieszka, et al.
Publicado: (2023)

Diversity of binary toxin positive Clostridioides difficile in Korea
por: Kim, Jieun, et al.
Publicado: (2023)

Detection of Free Toxin B in the Stool of Asymptomatic Clostridioides difficile Carriers by the Cell Cytotoxicity Neutralization Assay
por: Schweitzer, Lorne, et al.
Publicado: (2021)

1092. Tuning Down Clostridioides difficile PCR Sensitivity Reduces Treatment for C. difficile Infection in Toxin-Negative Patients With No Increase in Adverse Outcomes
por: Hitchcock, Matthew, et al.
Publicado: (2018)

A Segment of 97 Amino Acids within the Translocation Domain of Clostridium difficile Toxin B Is Essential for Toxicity
por: Zhang, Yongrong, et al.
Publicado: (2013)

Human α-Defensin-5 Efficiently Neutralizes Clostridioides difficile Toxins TcdA, TcdB, and CDT
por: Korbmacher, Michael, et al.
Publicado: (2020)

Human α-Defensin-6 Neutralizes Clostridioides difficile Toxins TcdA and TcdB by Direct Binding
por: Barthold, Lara, et al.
Publicado: (2022)

The Enterotoxicity of Clostridium difficile Toxins
por: Sun, Xingmin, et al.
Publicado: (2010)

Impact of deoxycholate on Clostridioides difficile growth, toxin production, and sporulation
por: Usui, Yukino, et al.
Publicado: (2020)

The Importance of Therapeutically Targeting the Binary Toxin from Clostridioides difficile
por: Abeyawardhane, Dinendra L., et al.
Publicado: (2021)

Binary Toxin Expression by Clostridioides difficile Is Associated With Worse Disease
por: Young, Mary K, et al.
Publicado: (2022)

Iron Effects on Clostridioides difficile Toxin Production and Antimicrobial Susceptibilities
por: Yamaki, Jason, et al.
Publicado: (2022)

Tauroursodeoxycholic Acid Inhibits Clostridioides difficile Toxin-Induced Apoptosis
por: Pike, Colleen M., et al.
Publicado: (2022)

The cytotoxic synergy between Clostridioides difficile toxin B and proinflammatory cytokines: an unholy alliance favoring the onset of Clostridioides difficile infection and relapses
por: Bassotti, Gabrio, et al.
Publicado: (2020)

Establishment of a Novel Detection Platform for Clostridioides difficile Toxin Genes Based on Orthogonal CRISPR
por: Jiang, Tong, et al.
Publicado: (2023)

Structure of the full-length Clostridium difficile toxin B
por: Chen, Peng, et al.
Publicado: (2019)

Inhibition of Clostridioides difficile Toxins TcdA and TcdB by Ambroxol
por: Heber, Sebastian, et al.
Publicado: (2022)

Glucosyltransferase-dependent and independent effects of Clostridioides difficile toxins during infection
por: Peritore-Galve, F. Christopher, et al.
Publicado: (2022)

Characterization and Pharmacological Inhibition of the Pore-Forming Clostridioides difficile CDTb Toxin
por: Ernst, Katharina, et al.
Publicado: (2021)

The TcdE holin drives toxin secretion and virulence in Clostridioides difficile
por: DiBenedetto, NV, et al.
Publicado: (2023)

Selection and characterization of ultrahigh potency designed ankyrin repeat protein inhibitors of C. difficile toxin B
por: Simeon, Rudo, et al.
Publicado: (2019)

Retargeting Clostridium difficile Toxin B to Neuronal Cells as a Potential Vehicle for Cytosolic Delivery of Therapeutic Biomolecules to Treat Botulism
por: Krautz-Peterson, Greice, et al.
Publicado: (2012)

Correction: Selection and characterization of ultrahigh potency designed ankyrin repeat protein inhibitors of C. difficile toxin B
por: Simeon, Rudo, et al.
Publicado: (2019)

Expression and (Lacking) Internalization of the Cell Surface Receptors of Clostridioides difficile Toxin B
por: Schöttelndreier, Dennis, et al.
Publicado: (2018)

Metabolic Reprogramming of Clostridioides difficile During the Stationary Phase With the Induction of Toxin Production
por: Hofmann, Julia D., et al.
Publicado: (2018)

RstA Is a Major Regulator of Clostridioides difficile Toxin Production and Motility
por: Edwards, Adrianne N., et al.
Publicado: (2019)

The Conserved Cys-2232 in Clostridioides difficile Toxin B Modulates Receptor Binding
por: Chung, Soo-Young, et al.
Publicado: (2018)

Eosinopenia and Binary Toxin Increase Mortality in Hospitalized Patients With Clostridioides difficile Infection
por: Carlson, Travis J, et al.
Publicado: (2020)

Structural Insights into the Transition of Clostridioides difficile Binary Toxin from Prepore to Pore
por: Anderson, David M., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_adp2gugqgqasuud7j2a0of8l7n