Molecular mechanism of the common and opposing cosolvent effects of fluorinated alcohol and urea on a coiled coil protein

Alcohols and urea are widely used as effective protein denaturants. Among monohydric alcohols, 2,2,2‐trifluoroethanol (TFE) has large cosolvent effects as a helix stabilizer in proteins. In contrast, urea efficiently denatures ordered native structures, including helices, into coils. These opposing...

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Detalles Bibliográficos
Autores principales: Nakata, Noa, Okamoto, Ryuichi, Sumi, Tomonari, Koga, Kenichiro, Morita, Takeshi, Imamura, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519159/
https://www.ncbi.nlm.nih.gov/pubmed/37622187
http://dx.doi.org/10.1002/pro.4763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519159/
https://www.ncbi.nlm.nih.gov/pubmed/37622187
http://dx.doi.org/10.1002/pro.4763

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