Design, synthesis, conformational analysis, and biological activity of Cα(1)-to-Cα(6) 1,4- and 4,1-disubstituted 1H-[1,2,3]triazol-1-yl-bridged oxytocin analogues

Oxytocin (OT) is a neurohypophyseal peptide hormone containing a disulphide-bridged pseudocyclic conformation. The biomedical use of OT peptides is limited amongst others by disadvantageous pharmacokinetic parameters. To increase the stability of OT by replacing the disulphide bridge with the stable...

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Detalles Bibliográficos
Autores principales: Nuti, Francesca, Larregola, Maud, Staśkiewicz, Agnieszka, Retzl, Bernhard, Tomašević, Nataša, Macchia, Lorenzo, Street, Maria E., Jewgiński, Michał, Lequin, Olivier, Latajka, Rafal, Rovero, Paolo, Gruber, Christian W., Chorev, Michael, Papini, Anna Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519257/
https://www.ncbi.nlm.nih.gov/pubmed/37735942
http://dx.doi.org/10.1080/14756366.2023.2254019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519257/
https://www.ncbi.nlm.nih.gov/pubmed/37735942
http://dx.doi.org/10.1080/14756366.2023.2254019

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