Identification of tyrosine sulfation in the variable region of a bispecific antibody and its effect on stability and biological activity

Despite tyrosine sulfation being a relatively common post-translational modification (PTM) on the secreted proteins of higher eukaryotic organisms, there have been surprisingly few reports of this modification occurring in recombinant monoclonal antibodies (mAbs) expressed by mammalian cell lines an...

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Detalles Bibliográficos
Autores principales: Lietz, Christopher B., Deyanova, Ekaterina, Cho, Younhee, Cordia, Jon, Franc, Sarah, Kabro, Sally, Wang, Steven, Mikolon, David, Banks, Douglas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519368/
https://www.ncbi.nlm.nih.gov/pubmed/37742207
http://dx.doi.org/10.1080/19420862.2023.2259289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519368/
https://www.ncbi.nlm.nih.gov/pubmed/37742207
http://dx.doi.org/10.1080/19420862.2023.2259289

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