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Identification of tyrosine sulfation in the variable region of a bispecific antibody and its effect on stability and biological activity
Despite tyrosine sulfation being a relatively common post-translational modification (PTM) on the secreted proteins of higher eukaryotic organisms, there have been surprisingly few reports of this modification occurring in recombinant monoclonal antibodies (mAbs) expressed by mammalian cell lines an...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519368/ https://www.ncbi.nlm.nih.gov/pubmed/37742207 http://dx.doi.org/10.1080/19420862.2023.2259289 |