Natalizumab Treatment Induces Proinflammatory CD4 T Cells Preferentially in the Integrin β7+ Compartment

BACKGROUND AND OBJECTIVES: Natalizumab, a monoclonal humanized antibody targeting integrin α4, inhibits the transmigration of lymphocytes into the CNS by preventing the interaction of integrin α4β1 with V-CAM expressed on brain vascular endothelial cells. Although natalizumab treatment reduces the c...

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Detalles Bibliográficos
Autores principales: Nguyen Ky, Mélanie, Duran, Adrien, Hasantari, Iris, Bru, Agnès, Deloire, Mathilde, Brochet, Bruno, Ruet, Aurélie, Schmitt, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519437/
https://www.ncbi.nlm.nih.gov/pubmed/37739811
http://dx.doi.org/10.1212/NXI.0000000000200166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519437/
https://www.ncbi.nlm.nih.gov/pubmed/37739811
http://dx.doi.org/10.1212/NXI.0000000000200166

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