Protocol for (E)-selective semihydrogenation of alkynes using iridium-based catalyst

In this protocol, we describe highly (E)-selective alkyne semihydrogenation employing commercially available iridium complex and a bidentate phosphine ligand. We provide steps for (E)-stilbene synthesis, remaining formic acid neutralization, and determination of the (Z)/(E) ratio using gas chromatog...

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Detalles Bibliográficos
Autores principales: Kusy, Rafał, Grela, Karol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519852/
https://www.ncbi.nlm.nih.gov/pubmed/37733598
http://dx.doi.org/10.1016/j.xpro.2023.102579
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author Kusy, Rafał
Grela, Karol
author_facet Kusy, Rafał
Grela, Karol
author_sort Kusy, Rafał
collection PubMed
description In this protocol, we describe highly (E)-selective alkyne semihydrogenation employing commercially available iridium complex and a bidentate phosphine ligand. We provide steps for (E)-stilbene synthesis, remaining formic acid neutralization, and determination of the (Z)/(E) ratio using gas chromatography analysis. We then detail (E)-stilbene purification using a short pad of silica and NMR analysis. The protocol is compatible with a wide range of functionalities and different types of alkynes. For complete details on the use and execution of this protocol, please refer to Kusy et al. (2022).(1)
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spelling pubmed-105198522023-09-27 Protocol for (E)-selective semihydrogenation of alkynes using iridium-based catalyst Kusy, Rafał Grela, Karol STAR Protoc Protocol In this protocol, we describe highly (E)-selective alkyne semihydrogenation employing commercially available iridium complex and a bidentate phosphine ligand. We provide steps for (E)-stilbene synthesis, remaining formic acid neutralization, and determination of the (Z)/(E) ratio using gas chromatography analysis. We then detail (E)-stilbene purification using a short pad of silica and NMR analysis. The protocol is compatible with a wide range of functionalities and different types of alkynes. For complete details on the use and execution of this protocol, please refer to Kusy et al. (2022).(1) Elsevier 2023-09-20 /pmc/articles/PMC10519852/ /pubmed/37733598 http://dx.doi.org/10.1016/j.xpro.2023.102579 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Protocol
Kusy, Rafał
Grela, Karol
Protocol for (E)-selective semihydrogenation of alkynes using iridium-based catalyst
title Protocol for (E)-selective semihydrogenation of alkynes using iridium-based catalyst
title_full Protocol for (E)-selective semihydrogenation of alkynes using iridium-based catalyst
title_fullStr Protocol for (E)-selective semihydrogenation of alkynes using iridium-based catalyst
title_full_unstemmed Protocol for (E)-selective semihydrogenation of alkynes using iridium-based catalyst
title_short Protocol for (E)-selective semihydrogenation of alkynes using iridium-based catalyst
title_sort protocol for (e)-selective semihydrogenation of alkynes using iridium-based catalyst
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519852/
https://www.ncbi.nlm.nih.gov/pubmed/37733598
http://dx.doi.org/10.1016/j.xpro.2023.102579
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