Comparative analysis of drug-salt-polymer interactions by experiment and molecular simulation improves biopharmaceutical performance

The propensity of poorly water-soluble drugs to aggregate at supersaturation impedes their bioavailability. Supersaturated amorphous drug-salt-polymer systems provide an emergent approach to this problem. However, the effects of polymers on drug-drug interactions in aqueous phase are largely unexplo...

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Detalles Bibliográficos
Autores principales: Mukesh, Sumit, Mukherjee, Goutam, Singh, Ridhima, Steenbuck, Nathan, Demidova, Carolina, Joshi, Prachi, Sangamwar, Abhay T., Wade, Rebecca C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519957/
https://www.ncbi.nlm.nih.gov/pubmed/37749228
http://dx.doi.org/10.1038/s42004-023-01006-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10519957/
https://www.ncbi.nlm.nih.gov/pubmed/37749228
http://dx.doi.org/10.1038/s42004-023-01006-0

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