Construction of IgG–Fab(2) bispecific antibody via intein-mediated protein trans-splicing reaction

A bispecific antibody (bsAb) is a class of engineered antibody molecules that simultaneously binds to two different antigens by having two kinds of antigen-binding domains. One of the major obstacles for the bsAb production is the incorrect chain-pairing problem, wherein each heavy and light chain s...

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Detalles Bibliográficos
Autores principales: Yamada, Risa, Nakahara, Ishin, Kumagai, Izumi, Asano, Ryutaro, Nakanishi, Takeshi, Makabe, Koki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520027/
https://www.ncbi.nlm.nih.gov/pubmed/37749185
http://dx.doi.org/10.1038/s41598-023-43110-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520027/
https://www.ncbi.nlm.nih.gov/pubmed/37749185
http://dx.doi.org/10.1038/s41598-023-43110-0

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