Cargando…

In vivo label-free optical signatures of chemotherapy response in human pancreatic ductal adenocarcinoma patient-derived xenografts

Pancreatic cancer is a devastating disease often detected at later stages, necessitating swift and effective chemotherapy treatment. However, chemoresistance is common and its mechanisms are poorly understood. Here, label-free multi-modal nonlinear optical microscopy was applied to study microstruct...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Jaena, Sorrells, Janet E., Chaney, Eric J., Abdelrahman, Amro M., Yonkus, Jennifer A., Leiting, Jennifer L., Nelson, Heidi, Harrington, Jonathan J., Aksamitiene, Edita, Marjanovic, Marina, Groves, Peter D., Bushell, Colleen, Truty, Mark J., Boppart, Stephen A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520051/ https://www.ncbi.nlm.nih.gov/pubmed/37749184 http://dx.doi.org/10.1038/s42003-023-05368-y

Ejemplares similares

Label-free characterization of single extracellular vesicles using two-photon fluorescence lifetime imaging microscopy of NAD(P)H
por: Sorrells, Janet E., et al.
Publicado: (2021)

Label-free multimodal nonlinear optical imaging of needle biopsy cores for intraoperative cancer diagnosis
por: Yang, Lingxiao, et al.
Publicado: (2022)

Intraoperative Label-Free Multimodal Nonlinear Optical Imaging for Point-of-Procedure Cancer Diagnostics
por: Yang, Lingxiao, et al.
Publicado: (2021)

Successful Secondary Engraftment of Pancreatic Ductal Adenocarcinoma and Cholangiocarcinoma Patient-Derived Xenografts After Previous Failed Primary Engraftment()
por: Hernandez, Matthew C., et al.
Publicado: (2018)

Biomechanical sensing of in vivo magnetic nanoparticle hyperthermia-treated melanoma using magnetomotive optical coherence elastography
por: Huang, Pin-Chieh, et al.
Publicado: (2021)

Nonlinear Imaging Histopathology: A Pipeline to Correlate Gold-Standard Hematoxylin and Eosin Staining With Modern Nonlinear Microscopy
por: Tehrani, Kayvan Forouhesh, et al.
Publicado: (2023)

Rituximab Decreases Lymphoproliferative Tumor Formation in Hepatopancreaticobiliary and Gastrointestinal Cancer Patient-Derived Xenografts
por: Leiting, Jennifer L., et al.
Publicado: (2019)

Biliary tract cancer patient-derived xenografts: Surgeon impact on individualized medicine
por: Leiting, Jennifer L., et al.
Publicado: (2020)

Tracking the binding of multi-functional fluorescent tags for Alzheimer’s disease using quantitative multiphoton microscopy
por: Iyer, Rishyashring R., et al.
Publicado: (2022)

Mixed Acinar Neuroendocrine Carcinoma of the Pancreas: Comparative Population-Based Epidemiology of a Rare and Fatal Malignancy in The United States
por: Abdelrahman, Amro M., et al.
Publicado: (2023)

Cancer “Avatars”: Patient-Derived Xenograft Growth Correlation with Postoperative Recurrence and Survival in Pancreaticobiliary Cancer
por: Lynch, Isaac T, et al.
Publicado: (2023)

Label-free metabolic and structural profiling of dynamic biological samples using multimodal optical microscopy with sensorless adaptive optics
por: Iyer, Rishyashring R., et al.
Publicado: (2022)

THU482 The Cholesterol Metabolite, 27-hydroxycholesterol, Enhances The Secretion Of Cancer Promoting Extracellular Vesicles By Impairing Lysosomal Integrity
por: Gupta, Anasuya Das, et al.
Publicado: (2023)

Concurrence of extracellular vesicle enrichment and metabolic switch visualized label-free in the tumor microenvironment
por: Tu, Haohua, et al.
Publicado: (2017)

Real-time intraoperative diagnosis by deep neural network driven multiphoton virtual histology
por: You, Sixian, et al.
Publicado: (2019)

Differential Uptake of Antisense Oligonucleotides in Mouse Hepatocytes and Macrophages Revealed by Simultaneous Two-Photon Excited Fluorescence and Coherent Raman Imaging
por: Mukherjee, Prabuddha, et al.
Publicado: (2022)

Optimizing Nanopore Sequencing for Rapid Detection of Microbial Species and Antimicrobial Resistance in Patients at Risk of Surgical Site Infections
por: Whittle, Emma, et al.
Publicado: (2022)

Computational Photon Counting Using Multithreshold Peak Detection for Fast Fluorescence Lifetime Imaging Microscopy
por: Sorrells, Janet E., et al.
Publicado: (2022)

Intravital imaging by simultaneous label-free autofluorescence-multiharmonic microscopy
por: You, Sixian, et al.
Publicado: (2018)

Raman Spectroscopic Analysis Reveals Abnormal Fatty Acid Composition in Tumor Micro- and Macroenvironments in Human Breast and Rat Mammary Cancer
por: You, Sixian, et al.
Publicado: (2016)

Video-rate multimodal multiphoton imaging and three-dimensional characterization of cellular dynamics in wounded skin
por: Li, Joanne, et al.
Publicado: (2020)

Handheld Briefcase Optical Coherence Tomography with Real-Time Machine Learning Classifier for Middle Ear Infections
por: Won, Jungeun, et al.
Publicado: (2021)

Weakly Supervised Identification and Localization of Drug Fingerprints Based on Label-Free Hyperspectral CARS Microscopy
por: Shi, Jindou, et al.
Publicado: (2023)

Development of gemcitabine-resistant patient-derived xenograft models of pancreatic ductal adenocarcinoma
por: Miller, Aubrey L., et al.
Publicado: (2020)

Neoadjuvant Chemotherapy Switch in Borderline Resectable/Locally Advanced Pancreatic Cancer
por: Alva-Ruiz, Roberto, et al.
Publicado: (2021)

MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus
por: Godfrey, Jack D., et al.
Publicado: (2018)

Vascularization, Oxygenation, and the Effect of Sunitinib Treatment in Pancreatic Ductal Adenocarcinoma Xenografts
por: Gaustad, Jon-Vidar, et al.
Publicado: (2019)

Chemotherapy and Radiofrequency-Induced Mild Hyperthermia Combined Treatment of Orthotopic Pancreatic Ductal Adenocarcinoma Xenografts
por: Krzykawska-Serda, Martyna, et al.
Publicado: (2018)

Lymph node metastasis and the physicochemical micro-environment of pancreatic ductal adenocarcinoma xenografts
por: Andersen, Lise Mari K., et al.
Publicado: (2017)

Intraoperative visualization of the tumor microenvironment and quantification of extracellular vesicles by label-free nonlinear imaging
por: Sun, Yi, et al.
Publicado: (2018)

Non-invasive optical interferometry for the assessment of biofilm growth in the middle ear
por: Nguyen, Cac T., et al.
Publicado: (2010)

Zebrafish Patient-Derived Xenografts Identify Chemo-Response in Pancreatic Ductal Adenocarcinoma Patients
por: Usai, Alice, et al.
Publicado: (2021)

Yield of Staging Laparoscopy for Pancreatic Cancer in the Modern Era: Analysis of More than 1,000 Consecutive Patients
por: Gudmundsdottir, Hallbera, et al.
Publicado: (2023)

An expeditious and precise method for diameter reduction of venous aneurysm causing arteriovenous fistula steal syndrome
por: Yonkus, Jennifer A., et al.
Publicado: (2023)

Dynamic Tracking Algorithm for Time-Varying Neuronal Network Connectivity using Wide-Field Optical Image Video Sequences
por: Renteria, Carlos, et al.
Publicado: (2020)

Radiation Therapy for Retroperitoneal Sarcomas: Influences of Histology, Grade, and Size
por: Leiting, Jennifer L., et al.
Publicado: (2018)

Influence of tumour size on uptake of(111)In-DTPA-labelled pegylated liposomes in a human tumour xenograft model
por: Harrington, K J, et al.
Publicado: (2000)

Stain-free histopathology by programmable supercontinuum pulses
por: Tu, Haohua, et al.
Publicado: (2016)

Real-time three-dimensional optical coherence tomography image-guided core-needle biopsy system
por: Kuo, Wei-Cheng, et al.
Publicado: (2012)

A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression
por: Hutten, Stefan J., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_uhh0u81fafqk2sj59ve365njge