Blockade of interferon signaling decreases gut barrier integrity and promotes severe West Nile virus disease

The determinants of severe disease caused by West Nile virus (WNV) and why only ~1% of individuals progress to encephalitis remain poorly understood. Here, we use human and mouse enteroids, and a mouse model of pathogenesis, to explore the capacity of WNV to directly infect gastrointestinal (GI) tra...

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Detalles Bibliográficos
Autores principales: Lin, Shih-Ching, Zhao, Fang R., Janova, Hana, Gervais, Adrian, Rucknagel, Summer, Murray, Kristy O., Casanova, Jean-Laurent, Diamond, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520062/
https://www.ncbi.nlm.nih.gov/pubmed/37749080
http://dx.doi.org/10.1038/s41467-023-41600-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520062/
https://www.ncbi.nlm.nih.gov/pubmed/37749080
http://dx.doi.org/10.1038/s41467-023-41600-3

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