A Glycolipidated-liposomal peptide vaccine confers long-term mucosal protection against Streptococcus pyogenes via IL-17, macrophages and neutrophils

Mucosally active subunit vaccines are an unmet clinical need due to lack of licensed immunostimulants suitable for vaccine antigens. Here, we show that intranasal administration of liposomes incorporating: the Streptococcus pyogenes peptide antigen, J8; diphtheria toxoid as a source of T cell help;...

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Detalles Bibliográficos
Autores principales: Ozberk, Victoria, Zaman, Mehfuz, Lepletier, Ailin, Eskandari, Sharareh, Kaden, Jacqualine, Mills, Jamie-Lee, Calcutt, Ainslie, Dooley, Jessica, Huo, Yongbao, Langshaw, Emma L., Ulett, Glen C., Batzloff, Michael R., Good, Michael F., Pandey, Manisha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520070/
https://www.ncbi.nlm.nih.gov/pubmed/37749129
http://dx.doi.org/10.1038/s41467-023-41410-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520070/
https://www.ncbi.nlm.nih.gov/pubmed/37749129
http://dx.doi.org/10.1038/s41467-023-41410-7

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