Towards Model-Informed Precision Dosing of Voriconazole: Challenging Published Voriconazole Nonlinear Mixed-Effects Models with Real-World Clinical Data

BACKGROUND AND OBJECTIVES: Model-informed precision dosing (MIPD) frequently uses nonlinear mixed-effects (NLME) models to predict and optimize therapy outcomes based on patient characteristics and therapeutic drug monitoring data. MIPD is indicated for compounds with narrow therapeutic range and co...

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Detalles Bibliográficos
Autores principales: Kluwe, Franziska, Michelet, Robin, Huisinga, Wilhelm, Zeitlinger, Markus, Mikus, Gerd, Kloft, Charlotte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520167/
https://www.ncbi.nlm.nih.gov/pubmed/37603216
http://dx.doi.org/10.1007/s40262-023-01274-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520167/
https://www.ncbi.nlm.nih.gov/pubmed/37603216
http://dx.doi.org/10.1007/s40262-023-01274-y

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