A novel phosphorylation site involved in dissociating RAF kinase from the scaffolding protein 14-3-3 and disrupting RAF dimerization

Rapidly accelerated fibrosarcoma (ARAF, BRAF, CRAF) kinase is central to the MAPK pathway (RAS–RAF–MEK–ERK). Inactive RAF kinase is believed to be monomeric, autoinhibited, and cytosolic, while activated RAF is recruited to the membrane via RAS-GTP, leading to the relief of autoinhibition, phosphory...

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Detalles Bibliográficos
Autores principales: Yu, Alison, Nguyen, Duc Huy, Nguyen, Thomas Joseph, Wang, Zhihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520314/
https://www.ncbi.nlm.nih.gov/pubmed/37625591
http://dx.doi.org/10.1016/j.jbc.2023.105188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520314/
https://www.ncbi.nlm.nih.gov/pubmed/37625591
http://dx.doi.org/10.1016/j.jbc.2023.105188

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