Cargando…

Novel exported fusion enzymes with chorismate mutase and cyclohexadienyl dehydratase activity: Shikimate pathway enzymes teamed up in no man's land

Chorismate mutase (CM) and cyclohexadienyl dehydratase (CDT) catalyze two subsequent reactions in the intracellular biosynthesis of l-phenylalanine (Phe). Here, we report the discovery of novel and extremely rare bifunctional fusion enzymes, consisting of fused CM and CDT domains, which are exported...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stocker, Christian, Khatanbaatar, Tamjidmaa, Bressan, Luca, Würth-Roderer, Kathrin, Cordara, Gabriele, Krengel, Ute, Kast, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520331/ https://www.ncbi.nlm.nih.gov/pubmed/37586588 http://dx.doi.org/10.1016/j.jbc.2023.105161

Ejemplares similares

What Drives Chorismate Mutase to Top Performance? Insights from a Combined In Silico and In Vitro Study
por: Thorbjørnsrud, Helen V., et al.
Publicado: (2023)

Evolving the naturally compromised chorismate mutase from Mycobacterium tuberculosis to top performance
por: Fahrig-Kamarauskait≑, Jūrate˙, et al.
Publicado: (2020)

Putative Bifunctional Chorismate Mutase/Prephenate Dehydratase Contributes to the Virulence of Acidovorax citrulli
por: Kim, Minyoung, et al.
Publicado: (2020)

Preliminary X-ray crystallographic analysis of the secreted chorismate mutase from Mycobacterium tuberculosis: a tricky crystallization problem solved
por: Krengel, Ute, et al.
Publicado: (2006)

Quantum chemical modeling of the reaction path of chorismate mutase based on the experimental substrate/product complex
por: Burschowsky, Daniel, et al.
Publicado: (2017)

Comprehensive database of Chorismate synthase enzyme from shikimate pathway in pathogenic bacteria
por: Pitchandi, Prabakaran, et al.
Publicado: (2013)

The role of oligomerization in the optimization of cyclohexadienyl dehydratase conformational dynamics and catalytic activity
por: East, Nicholas J., et al.
Publicado: (2022)

Bacterial bifunctional chorismate mutase-prephenate dehydratase PheA increases flux into the yeast phenylalanine pathway and improves mandelic acid production
por: Reifenrath, Mara, et al.
Publicado: (2018)

The importance of chorismate mutase in the biocontrol potential of Trichoderma parareesei
por: Pérez, Esclaudys, et al.
Publicado: (2015)

Mechanism of chorismate dehydratase MqnA, the first enzyme of the futalosine pathway, proceeds via substrate-assisted catalysis
por: Prasad, Archna, et al.
Publicado: (2022)

Chorismate mutase peptide antibody enables specific detection of Acanthamoeba
por: Lee, Hae-Ahm, et al.
Publicado: (2021)

Functional Analysis of 3-Dehydroquinate Dehydratase/Shikimate Dehydrogenases Involved in Shikimate Pathway in Camellia sinensis
por: Huang, Keyi, et al.
Publicado: (2019)

Horizontal gene transfer of acetyltransferases, invertases and chorismate mutases from different bacteria to diverse recipients
por: Noon, Jason B., et al.
Publicado: (2016)

Unraveling the kinetic diversity of microbial 3-dehydroquinate dehydratases of shikimate pathway
por: Liu, Chang, et al.
Publicado: (2015)

Evaluating the Diagnostic Potential of Chorismate Mutase Poly-Clonal Peptide Antibody for the Acanthamoeba Keratitis in an Animal Model
por: Kim, Min-Jeong, et al.
Publicado: (2023)

A Secreted Chorismate Mutase from Xanthomonas arboricola pv. juglandis Attenuates Virulence and Walnut Blight Symptoms
por: Assis, Renata de A. B., et al.
Publicado: (2021)

Identification of Polyketide Inhibitors Targeting 3-Dehydroquinate Dehydratase in the Shikimate Pathway of Enterococcus faecalis
por: Cheung, Vivian Wing Ngar, et al.
Publicado: (2014)

The emerging periplasm-localized subclass of AroQ chorismate mutases, exemplified by those from Salmonella typhimurium and Pseudomonas aeruginosa
por: Calhoun, David H, et al.
Publicado: (2001)

SKPDB: a structural database of shikimate pathway enzymes
por: Arcuri, Helen A, et al.
Publicado: (2010)

Over-Expression of Chorismate Mutase Enhances the Accumulation of Salicylic Acid, Lignin, and Antioxidants in Response to the White-Backed Planthopper in Rice Plants
por: Jan, Rahmatullah, et al.
Publicado: (2021)

Dehydroquinate dehydratase/shikimate dehydrogenases involved in gallate biosynthesis of the aluminum-tolerant tree species Eucalyptus camaldulensis
por: Tahara, Ko, et al.
Publicado: (2020)

Structure of Chorismate Mutase-like Domain of DAHPS from Bacillus subtilis Complexed with Novel Inhibitor Reveals Conformational Plasticity of Active Site
por: Pratap, Shivendra, et al.
Publicado: (2017)

The crystal structure of D-xylonate dehydratase reveals functional features of enzymes from the Ilv/ED dehydratase family
por: Rahman, Mohammad Mubinur, et al.
Publicado: (2018)

Synthesis, biological activity and molecular modelling studies of shikimic acid derivatives as inhibitors of the shikimate dehydrogenase enzyme of Escherichia coli
por: Díaz-Quiroz, Dulce Catalina, et al.
Publicado: (2018)

Chorismate mutase and isochorismatase, two potential effectors of the migratory nematode Hirschmanniella oryzae, increase host susceptibility by manipulating secondary metabolite content of rice
por: Bauters, Lander, et al.
Publicado: (2020)

An Evolutionary Conservation and Druggability Analysis of Enzymes Belonging to the Bacterial Shikimate Pathway
por: Frlan, Rok
Publicado: (2022)

Functional Mapping of Protein-Protein Interactions in an Enzyme Complex by Directed Evolution
por: Roderer, Kathrin, et al.
Publicado: (2014)

Potential of Mycobacterium tuberculosis chorismate mutase (Rv1885c) as a novel TLR4-mediated adjuvant for dendritic cell-based cancer immunotherapy
por: Jeong, Hyein, et al.
Publicado: (2022)

Crystal structure of MOA in complex with a peptide fragment: A protease caught in flagranti
por: Manna, Dipankar, et al.
Publicado: (2020)

Chitinolytic enzymes contribute to the pathogenicity of Aliivibrio salmonicida LFI1238 in the invasive phase of cold-water vibriosis
por: Skåne, Anna, et al.
Publicado: (2022)

Crystal Structures of Type I Dehydroquinate Dehydratase in Complex with Quinate and Shikimate Suggest a Novel Mechanism of Schiff Base Formation
por: Light, Samuel H., et al.
Publicado: (2014)

Novel isatin–indole derivatives as potential inhibitors of chorismate mutase (CM): their synthesis along with unexpected formation of 2-indolylmethylamino benzoate ester under Pd–Cu catalysis
por: Reddy, Gangireddy Sujeevan, et al.
Publicado: (2020)

Pd/Cu-catalyzed access to novel 3-(benzofuran-2-ylmethyl) substituted (pyrazolo/benzo)triazinone derivatives: their in silico/in vitro evaluation as inhibitors of chorismate mutase (CM)
por: Reddy, Gangireddy Sujeevan, et al.
Publicado: (2022)

Mycobacterium tuberculosis Shikimate Pathway Enzymes as Targets for the Rational Design of Anti-Tuberculosis Drugs
por: Nunes, José E. S., et al.
Publicado: (2020)

Molecular analysis and essentiality of Aro1 shikimate biosynthesis multi-enzyme in Candida albicans
por: Stogios, Peter J, et al.
Publicado: (2022)

Cofactor Selectivity in Methylmalonyl Coenzyme A Mutase, a Model Cobamide-Dependent Enzyme
por: Sokolovskaya, Olga M., et al.
Publicado: (2019)

Characterization of genetically modified mice for phosphoglycerate mutase, a vitally-essential enzyme in glycolysis
por: Mikawa, Takumi, et al.
Publicado: (2021)

Corrigendum to “Expression and Gene Regulation Network of Metabolic Enzyme Phosphoglycerate Mutase Enzyme 1 in Breast Cancer Based on Data Mining”
por: Wang, Yongxuan, et al.
Publicado: (2021)

Structures of the first representatives of Pfam family PF06684 (DUF1185) reveal a novel variant of the Bacillus chorismate mutase fold and suggest a role in amino-acid metabolism
por: Bakolitsa, Constantina, et al.
Publicado: (2010)

Structure and mechanism of a dehydratase/decarboxylase enzyme couple involved in polyketide β-methyl branch incorporation
por: Nair, Asha V., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_hs8ln5dj9se3eusja5t9ver6ag