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Oxidative stress induced by sustained supraphysiological intrastriatal GDNF delivery is prevented by dose regulation
Despite its established neuroprotective effect on dopaminergic neurons and encouraging phase I results, intraputaminal GDNF administration failed to demonstrate significant clinical benefits in Parkinson’s disease patients. Different human GDNF doses were delivered in the striatum of rats with a pro...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520444/ https://www.ncbi.nlm.nih.gov/pubmed/37766790 http://dx.doi.org/10.1016/j.omtm.2023.09.002 |