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Oxidative stress induced by sustained supraphysiological intrastriatal GDNF delivery is prevented by dose regulation

Despite its established neuroprotective effect on dopaminergic neurons and encouraging phase I results, intraputaminal GDNF administration failed to demonstrate significant clinical benefits in Parkinson’s disease patients. Different human GDNF doses were delivered in the striatum of rats with a pro...

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Detalles Bibliográficos
Autores principales:	Azevedo, Marcelo Duarte, Prince, Naika, Humbert-Claude, Marie, Mesa-Infante, Virginia, Jeanneret, Cheryl, Golzne, Valentine, De Matos, Kevin, Jamot, Benjamin Boury, Magara, Fulvio, Gonzalez-Hernandez, Tomas, Tenenbaum, Liliane
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520444/ https://www.ncbi.nlm.nih.gov/pubmed/37766790 http://dx.doi.org/10.1016/j.omtm.2023.09.002

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