CD38‐Specific CAR Integrated into CD38 Locus Driven by Different Promoters Causes Distinct Antitumor Activities of T and NK Cells

The robust and stable expression of CD38 in T‐cell acute lymphoblastic leukemia (T‐ALL) blasts makes CD38 chimeric antigen receptor (CAR)‐T/natural killer (NK) a potential therapy for T‐ALL. However, CD38 expression in normal T/NK cells causes fratricide of CD38 CAR‐T/NK cells. Here a “2‐in‐1” gene...

Descripción completa

Detalles Bibliográficos
Autores principales: Liao, Chan, Wang, Yajie, Huang, Yanjie, Duan, Yanting, Liang, Yan, Chen, Jiangqing, Jiang, Jie, Shang, Kai, Zhou, Chun, Gu, Ying, Liu, Nan, Zeng, Xun, Gao, Xiaofei, Tang, Yongmin, Sun, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520621/
https://www.ncbi.nlm.nih.gov/pubmed/37485647
http://dx.doi.org/10.1002/advs.202207394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520621/
https://www.ncbi.nlm.nih.gov/pubmed/37485647
http://dx.doi.org/10.1002/advs.202207394

Ejemplares similares