Structural Basis for the Enzymatic Activity of the HACE1 HECT‐Type E3 Ligase Through N‐Terminal Helix Dimerization

HACE1 is an ankyrin repeat (AKR) containing HECT‐type E3 ubiquitin ligase that interacts with and ubiquitinates multiple substrates. While HACE1 is a well‐known tumor suppressor, its structure and mode of ubiquitination are not understood. The authors present the cryo‐EM structures of human HACE1 al...

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Detalles Bibliográficos
Autores principales: Singh, Sunil, Machida, Satoru, Tulsian, Nikhil Kumar, Choong, Yeu Khai, Ng, Joel, Shankar, Srihari, Liu, Yaochen, Chandiramani, Krisha Vashdev, Shi, Jian, Sivaraman, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520629/
https://www.ncbi.nlm.nih.gov/pubmed/37537642
http://dx.doi.org/10.1002/advs.202207672

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520629/
https://www.ncbi.nlm.nih.gov/pubmed/37537642
http://dx.doi.org/10.1002/advs.202207672

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