Targeting Alpha‐Ketoglutarate Disruption Overcomes Immunoevasion and Improves PD‐1 Blockade Immunotherapy in Renal Cell Carcinoma

The Warburg effect‐related metabolic dysfunction of the tricarboxylic acid (TCA) cycle has emerged as a hallmark of various solid tumors, particularly renal cell carcinoma (RCC). RCC is characterized by high immune infiltration and thus recommended for immunotherapeutic interventions at an advanced...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Le, Zeng, Xing, Chao, Zheng, Luo, Jing, Guan, Wei, Zhang, Qiang, Ge, Yue, Wang, Yanan, Xiong, Zezhong, Ma, Sheng, Zhou, Qiang, Zhang, Junbiao, Tian, Jihua, Horne, David, Yuh, Bertram, Hu, Zhiquan, Wei, Gong‐Hong, Wang, Baojun, Zhang, Xu, Lan, Peixiang, Wang, Zhihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520657/
https://www.ncbi.nlm.nih.gov/pubmed/37526345
http://dx.doi.org/10.1002/advs.202301975

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520657/
https://www.ncbi.nlm.nih.gov/pubmed/37526345
http://dx.doi.org/10.1002/advs.202301975

Ejemplares similares