Bone-homing metastatic breast cancer cells impair osteocytes’ mechanoresponse in a 3D loading model

Breast cancer predominantly metastasizes to the skeleton. Mechanical loading is reliably anabolic in bone, and also inhibits bone metastatic tumor formation and bone loss in vivo. To study the underlying mechanisms, we developed a 3D culture model for osteocytes, the primary bone mechanosensor. We v...

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Detalles Bibliográficos
Autores principales: Sarazin, Blayne A., Liu, Boyuan, Goldman, Elaine, Whitefield, Ashlyn N., Lynch, Maureen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520780/
https://www.ncbi.nlm.nih.gov/pubmed/37767467
http://dx.doi.org/10.1016/j.heliyon.2023.e20248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520780/
https://www.ncbi.nlm.nih.gov/pubmed/37767467
http://dx.doi.org/10.1016/j.heliyon.2023.e20248

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