AAV-BDNF gene therapy ameliorates a hypothalamic neuroinflammatory signature in the Magel2-null model of Prader-Willi syndrome

Individuals with Prader-Willi syndrome (PWS) exhibit several metabolic and behavioral abnormalities associated with excessive food-seeking activity. PWS is thought to be driven in part by dysfunctional hypothalamic circuitry and blunted responses to peripheral signals of satiety. Previous work descr...

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Detalles Bibliográficos
Autores principales: Queen, Nicholas J., Huang, Wei, Zou, Xunchang, Mo, Xiaokui, Cao, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520877/
https://www.ncbi.nlm.nih.gov/pubmed/37766791
http://dx.doi.org/10.1016/j.omtm.2023.09.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520877/
https://www.ncbi.nlm.nih.gov/pubmed/37766791
http://dx.doi.org/10.1016/j.omtm.2023.09.004

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