Cargando…
GDF15 deficiency hinders human trophoblast invasion to mediate pregnancy loss through downregulating Smad1/5 phosphorylation
Growth differentiation factor 15 (GDF15) belongs to the Transforming growth factor β(TGF-β) superfamily. The decrease of GDF15 in the serum of pregnant women was associated with miscarriage. Both IHC and ELISA assays showed that GDF15 in trophoblast tissue and serum of pregnant women who miscarried...
Autores principales: | Zeng, Yu-Ting, Liu, Wen-Fang, Zheng, Peng-Sheng, Li, Shan |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520888/ https://www.ncbi.nlm.nih.gov/pubmed/37766993 http://dx.doi.org/10.1016/j.isci.2023.107902 |
Ejemplares similares
-
Insufficient GDF15 expression predisposes women to unexplained recurrent pregnancy loss by impairing extravillous trophoblast invasion
por: Lyu, Chunzi, et al.
Publicado: (2023) -
Fragile X-Related Protein 1 (FXR1) Promotes Trophoblast Migration at Early Pregnancy via Downregulation of GDF-15 Expression
por: Hong, Wei, et al.
Publicado: (2021) -
TGF-β induces Smad2 Phosphorylation, ARE Induction, and Trophoblast Differentiation
por: Albers, Renee E., et al.
Publicado: (2018) -
Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy
por: Fejzo, M, et al.
Publicado: (2023) -
NAG-1/GDF15 Accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway
por: Min, K-W, et al.
Publicado: (2015)