Study of interaction energies between residues of the active site of Hsp90 and geldanamycin analogues using quantum mechanics/molecular mechanics methods

Background: Heat shock protein (Hsp90KDa) is a molecular chaperone involved in the process of cellular oncogenesis, hence its importance as a therapeutic target. Geldanamycin is an inhibitor of Hsp90 chaperone activity, which binds to the ATP binding site in the N-terminal domain of Hsp90. However,...

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Detalles Bibliográficos
Autores principales: Vivas-Reyes, Ricardo, Morales-Bayuelo, Alejando, Gueto, Carlos, Drosos, Juan C., Márquez Lázaro, Johana, Baldiris, Rosa, Ahumedo, Maicol, Vivas-Gomez, Catalina, Aparicio, Dilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521063/
https://www.ncbi.nlm.nih.gov/pubmed/37767457
http://dx.doi.org/10.12688/f1000research.20844.2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521063/
https://www.ncbi.nlm.nih.gov/pubmed/37767457
http://dx.doi.org/10.12688/f1000research.20844.2

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