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Hepatocyte-specific HDAC3 ablation promotes hepatocellular carcinoma in females by suppressing Foxa1/2

BACKGROUND: Hepatocellular carcinoma (HCC), the most common primary liver cancer, prevails mainly in males and has long been attributed to androgens and higher circumstantial levels of interleukin-6 (IL-6) produced by resident hepatic macrophages. METHODS: Constitutively hepatocyte-specific histone...

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Detalles Bibliográficos
Autores principales: Xu, Yahong, Zhu, Yongjie, Wu, Zhenru, Li, Shengfu, Shao, Mingyang, Tao, Qing, Xu, Qing, Chen, Yuwei, Shu, Yuke, Chen, Menglin, Zhou, Yongjie, Shi, Yujun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521566/
https://www.ncbi.nlm.nih.gov/pubmed/37752418
http://dx.doi.org/10.1186/s12885-023-11393-1