Cargando…

Hepatocyte-specific HDAC3 ablation promotes hepatocellular carcinoma in females by suppressing Foxa1/2

BACKGROUND: Hepatocellular carcinoma (HCC), the most common primary liver cancer, prevails mainly in males and has long been attributed to androgens and higher circumstantial levels of interleukin-6 (IL-6) produced by resident hepatic macrophages. METHODS: Constitutively hepatocyte-specific histone...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Yahong, Zhu, Yongjie, Wu, Zhenru, Li, Shengfu, Shao, Mingyang, Tao, Qing, Xu, Qing, Chen, Yuwei, Shu, Yuke, Chen, Menglin, Zhou, Yongjie, Shi, Yujun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521566/ https://www.ncbi.nlm.nih.gov/pubmed/37752418 http://dx.doi.org/10.1186/s12885-023-11393-1

Ejemplares similares

Glutamine synthetase-negative hepatocellular carcinoma has better prognosis and response to sorafenib treatment after hepatectomy
por: Shao, Mingyang, et al.
Publicado: (2023)

Loss of Numb promotes hepatic progenitor expansion and intrahepatic cholangiocarcinoma by enhancing Notch signaling
por: Shu, Yuke, et al.
Publicado: (2021)

Exosomes derived from human umbilical cord mesenchymal stem cells ameliorate IL-6-induced acute liver injury through miR-455-3p
por: Shao, Mingyang, et al.
Publicado: (2020)

Mettl14-Mediated m(6)A Modification Facilitates Liver Regeneration by Maintaining Endoplasmic Reticulum Homeostasis
por: Cao, Xiaoyue, et al.
Publicado: (2021)

Congenital biliary atresia is correlated with disrupted cell junctions and polarity caused by Cdc42 insufficiency in the liver
por: Zhou, Yongjie, et al.
Publicado: (2021)

Pathophysiological Changes in Rhesus Monkeys with Paraquat-Induced Pulmonary Fibrosis
por: Shao, Mingyang, et al.
Publicado: (2022)

Relationship Between Histone Deacetylase 3 (HDAC3) and Breast Cancer
por: Cui, Zhuhong, et al.
Publicado: (2018)

Loss of FoxA2 accelerates neoplastic changes in the intrahepatic bile duct partly via the MAPK signaling pathway
por: Shen, Junyi, et al.
Publicado: (2019)

FOXA1 can be modulated by HDAC3 in the progression of epithelial ovarian carcinoma
por: Lou, Tong, et al.
Publicado: (2022)

Peripheral infusion of human umbilical cord mesenchymal stem cells rescues acute liver failure lethality in monkeys
por: Guo, Gang, et al.
Publicado: (2019)

FOXA2 alleviates CCl(4)-induced liver fibrosis by protecting hepatocytes in mice
por: Wang, Wei, et al.
Publicado: (2017)

Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction
por: Nakamori, Daiki, et al.
Publicado: (2017)

Hippo Signaling Influences HNF4A and FOXA2 Enhancer Switching during Hepatocyte Differentiation
por: Alder, Olivia, et al.
Publicado: (2014)

Foxa1 Reduces Lipid Accumulation in Human Hepatocytes and Is Down-Regulated in Nonalcoholic Fatty Liver
por: Moya, Marta, et al.
Publicado: (2012)

Significance of the NOR1-FOXA1/HDAC2-Slug regulatory network in epithelial-mesenchymal transition of tumor cells
por: Wang, Wei, et al.
Publicado: (2016)

MicroRNA-212 suppresses tumor growth of human hepatocellular carcinoma by targeting FOXA1
por: Dou, Changwei, et al.
Publicado: (2015)

Hypoxia-induced LncRNA DACT3-AS1 upregulates PKM2 to promote metastasis in hepatocellular carcinoma through the HDAC2/FOXA3 pathway
por: Wang, Liyan, et al.
Publicado: (2022)

Integrative Genomic Analysis Identifies That SERPINA6-rs1998056 Regulated by FOXA/ERα Is Associated with Female Hepatocellular Carcinoma
por: Shen, Na, et al.
Publicado: (2014)

Fine-scale visualizing the hierarchical structure of mouse biliary tree with fluorescence microscopy method
por: Chen, Yuwei, et al.
Publicado: (2020)

Foxa1 and Foxa2 Are Required for Formation of the Intervertebral Discs
por: Maier, Jennifer A., et al.
Publicado: (2013)

Circulating monocytes accelerate acute liver failure by IL‐6 secretion in monkey
por: Guo, Gang, et al.
Publicado: (2018)

MiR‐17~92 ablation impairs liver regeneration in an estrogen‐dependent manner
por: Zhou, Yongjie, et al.
Publicado: (2016)

Conversion of mesenchymal stem cells into a canine hepatocyte-like cells by Foxa1 and Hnf4a
por: Nitta, Suguru, et al.
Publicado: (2020)

Deletion of interleukin-6 in monocytes/macrophages suppresses the initiation of hepatocellular carcinoma in mice
por: Kong, Lingxiang, et al.
Publicado: (2016)

FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation
por: Lee, Kihyun, et al.
Publicado: (2019)

Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance
por: Domanskyi, Andrii, et al.
Publicado: (2014)

Opposing Roles of FoxA1 and FoxA3 in Intrahepatic Cholangiocarcinoma Progression
por: Thanan, Raynoo, et al.
Publicado: (2020)

Expression and Regulation of Transcription Factor FoxA2 in Chronic Rhinosinusitis With and Without Nasal Polyps
por: Luo, Qing, et al.
Publicado: (2015)

MicroRNA-200a inhibits cell growth and metastasis by targeting Foxa2 in hepatocellular carcinoma
por: Chen, Shu-ying, et al.
Publicado: (2017)

Upregulation of miR-223 in the rat liver inhibits proliferation of hepatocytes under simulated microgravity
por: Chen, Yongjie, et al.
Publicado: (2017)

FOXA1 in prostate cancer
por: Dong, Hui-Yu, et al.
Publicado: (2022)

MicroRNA-212 inhibits hepatocellular carcinoma cell proliferation and induces apoptosis by targeting FOXA1
por: Tu, Huahua, et al.
Publicado: (2015)

FOXA1 inhibits hepatocellular carcinoma progression by suppressing PIK3R1 expression in male patients
por: He, Shujiao, et al.
Publicado: (2017)

Long Noncoding RNA LL35/Falcor Regulates Expression of Transcription Factor Foxa2 in Hepatocytes in Normal and Fibrotic Mouse Liver
por: Sergeeva, O. V., et al.
Publicado: (2019)

Loss of FOXA2 induces ER stress and hepatic steatosis and alters developmental gene expression in human iPSC-derived hepatocytes
por: Aghadi, Maryam, et al.
Publicado: (2022)

Conditional ablation of HDAC3 in islet beta cells results in glucose intolerance and enhanced susceptibility to STZ-induced diabetes
por: Chen, Wen-Bin, et al.
Publicado: (2016)

Risk Factor Analysis of Acute Kidney Injury After Microwave Ablation of Hepatocellular Carcinoma: A Retrospective Study
por: Yang, Yongfeng, et al.
Publicado: (2020)

A novel medication decision gene signature predicts response to individualized therapy and prognosis outcomes in hepatocellular carcinoma patients
por: Yuan, Jingsheng, et al.
Publicado: (2022)

The ratio of FoxA1 to FoxA2 in lung adenocarcinoma is regulated by LncRNA HOTAIR and chromatin remodeling factor LSH
por: Wang, Ranran, et al.
Publicado: (2015)

Genome-Wide Location Analysis Reveals Distinct Transcriptional Circuitry by Paralogous Regulators Foxa1 and Foxa2
por: Bochkis, Irina M., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_a4mpu1ntspmvsn9c0rp7ut082t