De Novo Design of a Highly Stable Ovoid TIM Barrel: Unlocking Pocket Shape towards Functional Design

The ability to finely control the structure of protein folds is an important prerequisite to functional protein design. The TIM barrel fold is an important target for these efforts as it is highly enriched for diverse functions in nature. Although a TIM barrel protein has been designed de novo, the...

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Detalles Bibliográficos
Autores principales: Chu, Alexander E., Fernandez, Daniel, Liu, Jingjia, Eguchi, Raphael R., Huang, Po-Ssu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAAS 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521652/
https://www.ncbi.nlm.nih.gov/pubmed/37850141
http://dx.doi.org/10.34133/2022/9842315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521652/
https://www.ncbi.nlm.nih.gov/pubmed/37850141
http://dx.doi.org/10.34133/2022/9842315

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