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When practice does not make a perfect - paradoxical learning curve in schizophrenia and bipolar disorder revealed by different serial reaction time task variants
INTRODUCTION: Our previous studies identified a paradoxical implicit motor learning curve in schizophrenia (SZ) and bipolar disorder (BD) patients. This study aimed to verify whether those previously observed deficits may be captured by a new version of the ambidextrous serial reaction time task (SR...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521726/ https://www.ncbi.nlm.nih.gov/pubmed/37766926 http://dx.doi.org/10.3389/fpsyt.2023.1238473 |
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author | Chrobak, Adrian Andrzej Siuda-Krzywicka, Katarzyna Soltys, Zbigniew Bielak, Sylwia Nowaczek, Dominik Żyrkowska, Aleksandra Fafrowicz, Magdalena Marek, Tadeusz Pęcherzewska, Ewa Kużdżał, Jan Starowicz-Filip, Anna Gorostowicz, Aleksandra Dudek, Dominika Siwek, Marcin |
author_facet | Chrobak, Adrian Andrzej Siuda-Krzywicka, Katarzyna Soltys, Zbigniew Bielak, Sylwia Nowaczek, Dominik Żyrkowska, Aleksandra Fafrowicz, Magdalena Marek, Tadeusz Pęcherzewska, Ewa Kużdżał, Jan Starowicz-Filip, Anna Gorostowicz, Aleksandra Dudek, Dominika Siwek, Marcin |
author_sort | Chrobak, Adrian Andrzej |
collection | PubMed |
description | INTRODUCTION: Our previous studies identified a paradoxical implicit motor learning curve in schizophrenia (SZ) and bipolar disorder (BD) patients. This study aimed to verify whether those previously observed deficits may be captured by a new version of the ambidextrous serial reaction time task (SRTT), prepared for use in the MRI. METHODS: This study involved 186 participants. A total of 97 participants (33 BD, 33 SZ, and 31 healthy controls, HCs) completed the original, unlimited time response variant of SRTT. A total of 90 individuals (30 BD, 30 SZ, and 30 HCs) underwent a newer, limited response time version of this procedure. RESULTS: There was no significant difference in terms of implicit motor learning indices between both limited and unlimited response time SRTT. Compared to HCs, SZ, and BD patients presented decreased indices of implicit motor learning. Both clinical groups showed a paradoxical learning pattern that differed significantly from the HCs. Moreover, in the SZ group, the pattern depended on the hand performing SRTT. DISCUSSION: The limited response time SRTT variant allowed us to replicate the findings of disrupted implicit motor learning in SZ and BD. The use of this paradigm in further neuroimaging studies may help to determine the neuronal underpinnings of this cognitive dysfunction in the abovementioned clinical groups. |
format | Online Article Text |
id | pubmed-10521726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105217262023-09-27 When practice does not make a perfect - paradoxical learning curve in schizophrenia and bipolar disorder revealed by different serial reaction time task variants Chrobak, Adrian Andrzej Siuda-Krzywicka, Katarzyna Soltys, Zbigniew Bielak, Sylwia Nowaczek, Dominik Żyrkowska, Aleksandra Fafrowicz, Magdalena Marek, Tadeusz Pęcherzewska, Ewa Kużdżał, Jan Starowicz-Filip, Anna Gorostowicz, Aleksandra Dudek, Dominika Siwek, Marcin Front Psychiatry Psychiatry INTRODUCTION: Our previous studies identified a paradoxical implicit motor learning curve in schizophrenia (SZ) and bipolar disorder (BD) patients. This study aimed to verify whether those previously observed deficits may be captured by a new version of the ambidextrous serial reaction time task (SRTT), prepared for use in the MRI. METHODS: This study involved 186 participants. A total of 97 participants (33 BD, 33 SZ, and 31 healthy controls, HCs) completed the original, unlimited time response variant of SRTT. A total of 90 individuals (30 BD, 30 SZ, and 30 HCs) underwent a newer, limited response time version of this procedure. RESULTS: There was no significant difference in terms of implicit motor learning indices between both limited and unlimited response time SRTT. Compared to HCs, SZ, and BD patients presented decreased indices of implicit motor learning. Both clinical groups showed a paradoxical learning pattern that differed significantly from the HCs. Moreover, in the SZ group, the pattern depended on the hand performing SRTT. DISCUSSION: The limited response time SRTT variant allowed us to replicate the findings of disrupted implicit motor learning in SZ and BD. The use of this paradigm in further neuroimaging studies may help to determine the neuronal underpinnings of this cognitive dysfunction in the abovementioned clinical groups. Frontiers Media S.A. 2023-09-12 /pmc/articles/PMC10521726/ /pubmed/37766926 http://dx.doi.org/10.3389/fpsyt.2023.1238473 Text en Copyright © 2023 Chrobak, Siuda-Krzywicka, Soltys, Bielak, Nowaczek, Żyrkowska, Fafrowicz, Marek, Pęcherzewska, Kużdżał, Starowicz-Filip, Gorostowicz, Dudek and Siwek. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Chrobak, Adrian Andrzej Siuda-Krzywicka, Katarzyna Soltys, Zbigniew Bielak, Sylwia Nowaczek, Dominik Żyrkowska, Aleksandra Fafrowicz, Magdalena Marek, Tadeusz Pęcherzewska, Ewa Kużdżał, Jan Starowicz-Filip, Anna Gorostowicz, Aleksandra Dudek, Dominika Siwek, Marcin When practice does not make a perfect - paradoxical learning curve in schizophrenia and bipolar disorder revealed by different serial reaction time task variants |
title | When practice does not make a perfect - paradoxical learning curve in schizophrenia and bipolar disorder revealed by different serial reaction time task variants |
title_full | When practice does not make a perfect - paradoxical learning curve in schizophrenia and bipolar disorder revealed by different serial reaction time task variants |
title_fullStr | When practice does not make a perfect - paradoxical learning curve in schizophrenia and bipolar disorder revealed by different serial reaction time task variants |
title_full_unstemmed | When practice does not make a perfect - paradoxical learning curve in schizophrenia and bipolar disorder revealed by different serial reaction time task variants |
title_short | When practice does not make a perfect - paradoxical learning curve in schizophrenia and bipolar disorder revealed by different serial reaction time task variants |
title_sort | when practice does not make a perfect - paradoxical learning curve in schizophrenia and bipolar disorder revealed by different serial reaction time task variants |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521726/ https://www.ncbi.nlm.nih.gov/pubmed/37766926 http://dx.doi.org/10.3389/fpsyt.2023.1238473 |
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