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Durable CRISPR-Based Epigenetic Silencing

Development of CRISPR-based epigenome editing tools is important for the study and engineering of biological behavior. Here, we describe the design of a reporter system for quantifying the ability of CRISPR epigenome editors to produce a stable gene repression. We characterize the dynamics of durabl...

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Detalles Bibliográficos
Autores principales: Nakamura, Muneaki, Ivec, Alexis E., Gao, Yuchen, Qi, Lei S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAAS 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521745/
https://www.ncbi.nlm.nih.gov/pubmed/37849948
http://dx.doi.org/10.34133/2021/9815820