Species-specific cleavage of cGAS by picornavirus protease 3C disrupts mitochondria DNA-mediated immune sensing

RNA viruses cause numerous infectious diseases in humans and animals. The crosstalk between RNA viruses and the innate DNA sensing pathways attracts increasing attention. Recent studies showed that the cGAS-STING pathway plays an important role in restricting RNA viruses via mitochondria DNA (mtDNA)...

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Detalles Bibliográficos
Autores principales: Yan, Ya, Wu, Lei, Yuan, Ye, Wang, Haiwei, Yin, Hongyan, Li, Minjie, Chai, Lvye, Liang, Ruiying, Liu, Yanjie, Zhao, Dongming, Xing, Junji, Li, Pingwei, Li, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521975/
https://www.ncbi.nlm.nih.gov/pubmed/37708231
http://dx.doi.org/10.1371/journal.ppat.1011641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521975/
https://www.ncbi.nlm.nih.gov/pubmed/37708231
http://dx.doi.org/10.1371/journal.ppat.1011641

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