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Notch pathway mutants do not equivalently perturb mouse embryonic retinal development

In the vertebrate eye, Notch ligands, receptors, and ternary complex components determine the destiny of retinal progenitor cells in part by regulating Hes effector gene activity. There are multiple paralogues for nearly every node in this pathway, which results in numerous instances of redundancy a...

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Detalles Bibliográficos
Autores principales: Bosze, Bernadett, Suarez-Navarro, Julissa, Cajias, Illiana, Brzezinski IV, Joseph A., Brown, Nadean L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522021/
https://www.ncbi.nlm.nih.gov/pubmed/37751417
http://dx.doi.org/10.1371/journal.pgen.1010928