Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease

This study shows that Elastic Net (EN) DNA methylation (DNAme) clocks have low accuracy of predictions for individuals of the same age and a low resolution between healthy and disease cohorts; caveats inherent in applying linear model to non-linear processes. We found that change in methylation of c...

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Detalles Bibliográficos
Autores principales: Mei, Xiaoyue, Blanchard, Joshua, Luellen, Connor, Conboy, Michael J., Conboy, Irina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2023
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522373/
https://www.ncbi.nlm.nih.gov/pubmed/37702598
http://dx.doi.org/10.18632/aging.205046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522373/
https://www.ncbi.nlm.nih.gov/pubmed/37702598
http://dx.doi.org/10.18632/aging.205046

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