Cargando…

MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange

Presentation of antigenic peptides by major histocompatibility complex class II (MHC-II) proteins determines T helper cell reactivity. The MHC-II genetic locus displays a large degree of allelic polymorphism influencing the peptide repertoire presented by the resulting MHC-II protein allotypes. Duri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abualrous, Esam T., Stolzenberg, Sebastian, Sticht, Jana, Wieczorek, Marek, Roske, Yvette, Günther, Matthias, Dähn, Steffen, Boesen, Benedikt B., Calvo, Marcos Martínez, Biese, Charlotte, Kuppler, Frank, Medina-García, Álvaro, Álvaro-Benito, Miguel, Höfer, Thomas, Noé, Frank, Freund, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522485/ https://www.ncbi.nlm.nih.gov/pubmed/37142807 http://dx.doi.org/10.1038/s41589-023-01316-3

Ejemplares similares

Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation
por: Wieczorek, Marek, et al.
Publicado: (2017)

MHC class II complexes sample intermediate states along the peptide exchange pathway
por: Wieczorek, Marek, et al.
Publicado: (2016)

Quantification of HLA-DM-Dependent Major Histocompatibility Complex of Class II Immunopeptidomes by the Peptide Landscape Antigenic Epitope Alignment Utility
por: Álvaro-Benito, Miguel, et al.
Publicado: (2018)

Dynamically Driven Allostery in MHC Proteins: Peptide-Dependent Tuning of Class I MHC Global Flexibility
por: Ayres, Cory M., et al.
Publicado: (2019)

Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules
por: Lan, Huan, et al.
Publicado: (2021)

Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes
por: Sun, Yi, et al.
Publicado: (2023)

Type 1 Diabetes and the HLA Region: Genetic Association Besides Classical HLA Class II Genes
por: Sticht, Jana, et al.
Publicado: (2021)

Xeno interactions between MHC-I proteins and molecular chaperones enable ligand exchange on a broad repertoire of HLA allotypes
por: Sun, Yi, et al.
Publicado: (2023)

Human leukocyte Antigen-DM polymorphisms in autoimmune diseases
por: Alvaro-Benito, Miguel, et al.
Publicado: (2016)

Distinct mechanisms survey the structural integrity of HLA-B*27:05 intracellularly and at the surface
por: Hein, Zeynep, et al.
Publicado: (2018)

Correction: Distinct mechanisms survey the structural integrity of HLA-B*27:05 intracellularly and at the surface
por: Hein, Zeynep, et al.
Publicado: (2018)

Towards Universal Structure-Based Prediction of Class II MHC Epitopes for Diverse Allotypes
por: Bordner, Andrew J.
Publicado: (2010)

Screening and Identification of HBV Epitopes Restricted by Multiple Prevalent HLA-A Allotypes
por: Ding, Yan, et al.
Publicado: (2022)

A novel post-transcriptional role for ubiquitin in the differential regulation of MHC class I allotypes()
por: Cano, Florencia, et al.
Publicado: (2013)

Author Correction: Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations
por: Paul, Fabian, et al.
Publicado: (2018)

Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations
por: Paul, Fabian, et al.
Publicado: (2017)

Selected HLA-B allotypes are resistant to inhibition or deficiency of the transporter associated with antigen processing (TAP)
por: Geng, Jie, et al.
Publicado: (2018)

Canonical and Cross-reactive Binding of NK Cell Inhibitory Receptors to HLA-C Allotypes Is Dictated by Peptides Bound to HLA-C
por: Sim, Malcolm J. W., et al.
Publicado: (2017)

Role of immune recognition in latent allotype induction and clearance. Evidence for an allotypic network
Publicado: (1981)

The Carboxy Terminus of the Ligand Peptide Determines the Stability of the MHC Class I Molecule H-2K(b): A Combined Molecular Dynamics and Experimental Study
por: Abualrous, Esam Tolba, et al.
Publicado: (2015)

Genetic variation that determines TAPBP expression levels associates with the course of malaria in an HLA allotype-dependent manner
por: Walker-Sperling, Victoria, et al.
Publicado: (2022)

HLA-G and the MHC Cusp Theory
por: Scavuzzi, Bruna Miglioranza, et al.
Publicado: (2022)

Monoclonal antibody to an IgD allotype induces a new type of allotype suppression in the mouse
Publicado: (1981)

The nature of antiidiotype molecules induced by antiallotype. Presence of both latent allotype and allotypic internal images
Publicado: (1985)

MultiRTA: A simple yet reliable method for predicting peptide binding affinities for multiple class II MHC allotypes
por: Bordner, Andrew J, et al.
Publicado: (2010)

Endo-lysosomal assembly variations among human leukocyte antigen class I (HLA class I) allotypes
por: Olson, Eli, et al.
Publicado: (2023)

A Missing Switch in Peptide Exchange for MHC Class II Molecules
por: Freund, Christian, et al.
Publicado: (2019)

A p70 killer cell inhibitory receptor specific for several HLA-B allotypes discriminates among peptides bound to HLA-B*2705
Publicado: (1996)

In vitro studies on allotype suppression. III. compounds of antiallyotype serum active in release from allotype suppression
Publicado: (1975)

Radioimmune analysis of an unexpected mouse allotype
Publicado: (1979)

Adaptive Admixture of HLA Class I Allotypes Enhanced Genetically Determined Strength of Natural Killer Cells in East Asians
por: Deng, Zhihui, et al.
Publicado: (2021)

Donor killer immunoglobulin-like receptor genes and reactivation of cytomegalovirus after HLA-matched hematopoietic stem-cell transplantation: HLA-C allotype is an essential cofactor
por: Behrendt, Carolyn E., et al.
Publicado: (2013)

AN IDIOTYPIC CROSS-REACTION BETWEEN ALLOTYPE a3 AND ALLOTYPE a NEGATIVE RABBIT ANTIBODIES TO STREPTOCOCCAL CARBOHYDRATE
por: Kindt, Thomas J., et al.
Publicado: (1973)

Ensuring equity in the era of HLA-restricted cancer therapeutics
por: Smithy, James W, et al.
Publicado: (2022)

Isotypic and allotypic specificity of mouse rheumatoid factors
Publicado: (1983)

Nonallelic behavior of rabbit variable-region allotypes
Publicado: (1975)

ALLOTYPE SUPPRESSION IN THE RABBIT : I. THE ONTOGENY OF CELLS BEARING IMMUNOGLOBULIN OF PATERNAL ALLOTYPE AND THE FATE OF THESE CELLS AFTER TREATMENT WITH ANTIALLOTYPE ANTISERA
por: Harrison, Michael R., et al.
Publicado: (1973)

Antigen-specific influence of GM/KM allotypes on IgG isotypes and association of GM allotypes with susceptibility to Plasmodium falciparum malaria
por: Giha, Hayder A, et al.
Publicado: (2009)

KIR2DS5 allotypes that recognize the C2 epitope of HLA‐C are common among Africans and absent from Europeans
por: Blokhuis, Jeroen H., et al.
Publicado: (2017)

Comprehensive analysis of mycobacterium tuberculosis antigen-specific CD4(+) T cell responses restricted by single HLA class II allotype in an individual
por: Lee, Yong-Hun, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2lu6vgvebtq6f9bee7iefua0mp