Loss of Notch signaling in skeletal stem cells enhances bone formation with aging

Skeletal stem and progenitor cells (SSPCs) perform bone maintenance and repair. With age, they produce fewer osteoblasts and more adipocytes leading to a loss of skeletal integrity. The molecular mechanisms that underlie this detrimental transformation are largely unknown. Single-cell RNA sequencing...

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Detalles Bibliográficos
Autores principales: Remark, Lindsey H., Leclerc, Kevin, Ramsukh, Malissa, Lin, Ziyan, Lee, Sooyeon, Dharmalingam, Backialakshmi, Gillinov, Lauren, Nayak, Vasudev V., El Parente, Paulo, Sambon, Margaux, Atria, Pablo J., Ali, Mohamed A. E., Witek, Lukasz, Castillo, Alesha B., Park, Christopher Y, Adams, Ralf H., Tsirigos, Aristotelis, Morgani, Sophie M., Leucht, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522593/
https://www.ncbi.nlm.nih.gov/pubmed/37752132
http://dx.doi.org/10.1038/s41413-023-00283-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522593/
https://www.ncbi.nlm.nih.gov/pubmed/37752132
http://dx.doi.org/10.1038/s41413-023-00283-8

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