The oleic/palmitic acid imbalance in exosomes isolated from NAFLD patients induces necroptosis of liver cells via the elongase-6/RIP-1 pathway

Excessive toxic lipid accumulation in hepatocytes underlies the development of non-alcoholic fatty liver disease (NAFLD), phenotypically characterized by necrosis and steato-fibrosis, whose molecular mechanism is not yet fully understood. Patients with NAFLD display an imbalanced palmitic (PA) to ol...

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Detalles Bibliográficos
Autores principales: Scavo, Maria Principia, Negro, Roberto, Arrè, Valentina, Depalo, Nicoletta, Carrieri, Livianna, Rizzi, Federica, Mastrogiacomo, Rita, Serino, Grazia, Notarnicola, Maria, De Nunzio, Valentina, Lippolis, Tamara, Pesole, Pasqua Letizia, Coletta, Sergio, Armentano, Raffaele, Curri, Maria Lucia, Giannelli, Gianluigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522611/
https://www.ncbi.nlm.nih.gov/pubmed/37752143
http://dx.doi.org/10.1038/s41419-023-06161-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522611/
https://www.ncbi.nlm.nih.gov/pubmed/37752143
http://dx.doi.org/10.1038/s41419-023-06161-9

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