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Mechanical stiffness promotes skin fibrosis through Piezo1-mediated arginine and proline metabolism
The increased mechanics of fibrotic skin tissue continuously regulate fibroblast functions such as survival and differentiation. Although all these processes consume metabolites, it is unclear whether and how cells adapt their metabolic activity to increased matrix stiffness. Here, we show that tran...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522626/ https://www.ncbi.nlm.nih.gov/pubmed/37752116 http://dx.doi.org/10.1038/s41420-023-01656-y |