Deglycosylation of eukaryotic-expressed flagellin restores adjuvanticity

Flagellin, the TLR5 agonist, shows potent adjuvant activities in diverse vaccines and immunotherapies. Vibrio vulnificus flagellin B expressed in eukaryotic cells (eFlaB) could not stimulate TLR5 signaling. Enzymatic deglycosylation restored eFlaB’s TLR5 stimulating functionality, suggesting that gl...

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Detalles Bibliográficos
Autores principales: Khim, Koemchhoy, Puth, Sao, Radhakrishnan, Kamalakannan, Nguyen, Tien Duc, Lee, Youn Suhk, Jung, Che-Hun, Lee, Shee Eun, Rhee, Joon Haeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522637/
https://www.ncbi.nlm.nih.gov/pubmed/37752138
http://dx.doi.org/10.1038/s41541-023-00738-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522637/
https://www.ncbi.nlm.nih.gov/pubmed/37752138
http://dx.doi.org/10.1038/s41541-023-00738-3

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