Orai inhibition modulates pulmonary ILC2 metabolism and alleviates airway hyperreactivity in murine and humanized models

Ca(2+) entry via Ca(2+) release-activated Ca(2+) (CRAC) channels is a predominant mechanism of intracellular Ca(2+) elevation in immune cells. Here we show the immunoregulatory role of CRAC channel components Orai1 and Orai2 in Group 2 innate lymphoid cells (ILC2s), that play crucial roles in the in...

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Detalles Bibliográficos
Autores principales: Howard, Emily, Hurrell, Benjamin P., Helou, Doumet Georges, Shafiei-Jahani, Pedram, Hasiakos, Spyridon, Painter, Jacob, Srikanth, Sonal, Gwack, Yousang, Akbari, Omid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522697/
https://www.ncbi.nlm.nih.gov/pubmed/37752127
http://dx.doi.org/10.1038/s41467-023-41065-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522697/
https://www.ncbi.nlm.nih.gov/pubmed/37752127
http://dx.doi.org/10.1038/s41467-023-41065-4

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